Obinna (Obi) Obianom, PhD, MS
Pharmacometrician & Software Engineer
- Google Scholar LinkedIn ORCID Cambridge, MA, USA
Executive Summary
Meticulous, task-driven professional with 6+ yrs experience in pharmacokinetic and pharmacodynamic analysis. Adept in software development with 15+ yrs experience using various programming languages. Strong inter-personal skills to interact with diverse individuals and groups at all organization levels.
Work Experience
Senior Scientist
Support PK/PD analysis for new drug development efforts in various therapeutic areas.
Assistant Director
Support PK/PD and PBPK analysis for new drug development efforts primarily using NONMEM, Gastroplus, Monolix, R and KIWI. A general focus on software development primarily using the R, Javascript and CSS languanges. Key developer of an R-based scientific presentation software called Vantage.
Scientist Developer I
Support PK/PD and PBPK analysis for new drug development efforts primarily using NONMEM, Gastroplus, Monolix, R and KIWI. A general focus on software development primarily using the R, Javascript and CSS languanges. Key developer of an R-based scientific presentation software called Vantage.
ORISE Fellow (Advisor: Theingi Thway, PhD)
Research investigation involving the use of pharmacometric analysis in understanding the effect of bias in bioanalytical method development for large-molecule drug candidates.
Graduate Researcher (Advisor: Yan Shu, PhD)
Triazole-based inhibitors of the Wnt/β-Catenin signaling pathway improve glucose and lipid metabolisms in diet-induced obese mice
Pharmacometric Intern (Advisor: Sebastien Bihorel, PhD)
Research Experience
Graduate Research Assistant, Pharmacy Department
Research work in bioanalysis, pharmacokinetics and pharmacogenomics of HIV drugs with Dr. Gene Morse; Research in Pharmacokinetics of GHB, a date-rape drug with Dr. Marilyn E. Morris.
Undergraduate Research Assistant, Biochemistry Department
Investigating the molecular mechanisms by which hormones, growth factors and extracellular matrix proteins regulate kidney tubule epithelial cell growth and functional differentiation in vitro with Dr. Mary Taub
Graduate Research Assistant, Chemistry Department
Synthesis and separation of enantiomers with Dr. Steven Diver
Teaching and Mentoring Experience
Teaching Assistant, University of Maryland, Baltimore
- Assisted multiple pharmacy professors in duties within the classroom
- Help grade and communicate results to students
Reports/Publication
- Divergent Regulation of OCT and MATE Drug Transporters by Cadmium Exposure. Pharmaceutics 2021 Apr 13;13(4); pii: 537. doi: 10.3390/pharmaceutics13040537
- Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-Catenin Downregulation and AMPK Activation. Pharmaceutics 2021 Mar 4;13(3); pii: 330. doi: 10.3390/pharmaceutics13030330
- Effects of Targeted Delivery of Metformin and Dental Pulp Stem Cells on Osteogenesis via Demineralized Dentin Matrix under High Glucose Conditions. ACS biomaterials science & engineering 2020 Apr 13;6(4); doi: 10.1021/acsbiomaterials.0c00124
- Cadmium exposure enhances organic cation transporter 2 trafficking to the kidney membrane and exacerbates cisplatin nephrotoxicity. Kidney international 2020 Apr;97(4); doi: 10.1016/j.kint.2019.11.012
- A Simulation Approach to Evaluate the Impact of Patterns of Bioanalytical Bias Difference on the Outcome of Pharmacokinetic Similarity Studies. Clinical pharmacology and therapeutics 2020 Jul;108(1); doi: 10.1002/cpt.1767
- Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. Journal of medicinal chemistry 2019 Dec 26;62(24); doi: 10.1021/acs.jmedchem.9b01252
- Retrospective Analysis of Bioanalytical Method Validation Approaches in Biosimilar Biological Product Development. The AAPS journal 2019 Sep 11;21(6); doi: 10.1208/s12248-019-0376-0
- The LRP6 functional mutation rs2302685 contributes to individual susceptibility to alcoholic liver injury related to the Wnt/β-catenin-TCF1-CYP2E1 signaling pathway. Archives of toxicology 2019 Jun;93(6); doi: 10.1007/s00204-019-02447-0
- Enhanced Tumor Selectivity of 5-Fluorouracil Using a Reactive Oxygen Species-Activated Prodrug Approach. ACS medicinal chemistry letters 2019 Jan 10;10(1); doi: 10.1021/acsmedchemlett.8b00539
- Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice. Journal of medicinal chemistry 2019 Jan 24;62(2); doi: 10.1021/acs.jmedchem.8b01408
- Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo. MedChemComm 2018 Oct 1;9(10); doi: 10.1039/c8md00284c
- Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. Pharmaceutical research 2018 Sep 6;35(11); doi: 10.1007/s11095-018-2486-2
- Novel cinnamaldehyde-based aspirin derivatives for the treatment of colorectal cancer. Bioorganic & medicinal chemistry letters 2018 Sep 15;28(17); doi: 10.1016/j.bmcl.2018.07.032
- Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2. Molecular pharmaceutics 2017 Aug 7;14(8); doi: 10.1021/acs.molpharmaceut.7b00285
- Multidrug and toxin extrusion proteins mediate cellular transport of cadmium. Toxicology and applied pharmacology 2017 Jan 1;314(); doi: 10.1016/j.taap.2016.11.007
Presentations
Tankyrases are druggable targets for the treatment of metabolic disorders
Ischemia‐Reperfusion‐Inducible Protein Modulates the Activity of Metabolizing Enzymes
Projects
Discovery of Novel WNT/B-catenin Pathway Inhibitors
Synthesis and biological characterizations of a novel class of WNT/B-catening pathway inhibitors
Using the Prodrug Approach in the Development of Novel Therapies
Synthesis and biological characterizations of a novel prodrugs to improve bioavailability of otherwise poorly permeable compounds
Tiny R Packages and Two Platforms for R
12+ R packages published and maintained in CRAN. rpkg.net is a platform that allows search through > 18,598 R packages, compare across various packages based on name or keywords in their descriptions.
Education
PhD in Pharmaceutical Sciences
Dissertation title: “CRISPR mediated deletion of TLE1 in mouse and its ensuing consequences”
Committee: Yan Shu | Marilyn Morris
Committee: Yan Shu | Marilyn Morris
MS in Pharmaceutical Sciences
BS in Pharmaceutical Sciences and Pharmacology/Toxicology
Expertise
Pharmacokinetics modelling
Pharmacodynamics modelling
PBPK modelling
Data analysis and compilation
R, NONMEM, Monolix
Interests
PK/PD analysis
R development
PB/PK analysis
Microsoft Suite
Full stack app development
Chess and Soccer
My Other Skills
Professional
- Writing
- Western Blot
- Gel Electro
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Medicinal Chemistry
Software
- PHP
- HTML5
- CSS
- Java
- Javascript
- ASP.net
- NONMEM
- R
- KIWI
- Vantage
- Monolix
- Berkeley Madonna
- Adobe suite
- Microsoft suite
- Web3
- MYSQL